Effects of visual information on the face masked speech communication in Covid-secure classrooms

Acoustical measurements and speech intelligibility tests were carried out to investigate the effects of masks on speech communication experienced in real Covid-secure university classrooms during the pandemic. Face-masked speech levels and noise levels were measured to understand the acoustical effects of masks on speech sounds during 15 multiple lectures in 3 university classrooms. The speech intelligibility scores were also evaluated for lower and higher SNR (signal-to-noise ratio) conditions, and for with and without the presence of visual information conditions to investigate the effects of both the acoustic and visual signals in understanding speech communication in actual classroom situations. In the 3 active university classrooms the students experienced on average: speech levels of 55.1 dBA (σ = 5.5 dBA), noise levels of 42.3 dBA (σ = 3.9 dBA), and a speech-to-noise ratio of 12.8 dBA σ = 5.2 dBA). The mean SNR values at the listener's position for the 15 lectures varied from 3.6 dBA to 20.0 dBA. The use of a portable sound amplification system increases the face-masked speech levels mostly at mid and high frequencies (500–4 kHz), thus it can be more useful for achieving higher SNR values in classrooms. The presence of visual cues have little effect on achieving more higher speech intelligibility scores in higher SNR conditions. The present results show that visual obstruction of the talker's mouth decreases speech intelligibility scores by a maximum of 10% in lower SNR conditions, particularly at a SNR of 6 dBA or lower. © 2023 Elsevier Ltd

Natural killer cells in sepsis: Friends or foes?

Sepsis is one of the major causes of death in the hospital worldwide. The pathology of sepsis is tightly associated with dysregulation of innate immune responses. The contribution of macrophages, neutrophils, and dendritic cells to sepsis is well documented, whereas the role of natural killer (NK) cells, which are critical innate lymphoid lineage cells, remains unclear. In some studies, the activation of NK cells has been reported as a risk factor leading to severe organ damage or death. In sharp contrast, some other studies revealed that triggering NK cell activity contributes to alleviating sepsis. In all, although there are several reports on NK cells in sepsis, whether they exert detrimental or protective effects remains unclear. Here, we will review the available experimental and clinical studies about the opposing roles of NK cells in sepsis, and we will discuss the prospects for NK cell-based immunotherapeutic strategies for sepsis.

Stress among Students and Difficulty with Time Management: A Study at the University of Galati in Romania

Stress is a defining trait of our modern societies. The correlations between economic and social developments and the state of ill-being of populations have long been demonstrated. Today, negative environmental factors such as climate change, war and health crises have consequences on populations. Regardless of gender or age, more and more people are suffering from stress, of which there are many effects. According to studies, stress is an emotional response resulting from human-environmental interaction. They define stress as a state of discomfort and tension caused by external factors. This author believes that stress has a negative impact, which leads to frustration and increased difficulty in addressing issues. Authors describes stress as a physical and psychological state experienced by someone facing a real or potential. For students, stress can be caused by a number of factors. Some of these may include how the university functions, exam periods, relationships with teachers, the pressure that parents put on academic achievement, competition with other students, financial problems, uncertainty about the future, and lack of self-confidence. Symptoms of stress are now well identified. Students suffering from stress report feeling unhappy, having stomach pains, difficulty relaxing and sleeping, mental health problems, and even depression. When it comes to stress, Romanian students are no exception, especially because of the particularly volatile situation faced by the nation. The country has high immigration of skilled and qualified labour, inflation, and depreciation of the national currency. Students also claim to be stressed by the challenges of student life and the demands of the working world. They have a constant fear of failure and doubt themselves, their academic skills, and success in their careers after graduating. Our sociological study aims to deepen our knowledge in this field in Romania. In an already anxious context, it successively examines stress factors, symptoms experienced by students, conditions for organising studies, and ways to improve students' quality of life. To conduct our study, we sampled students at the Dunarea de Jos University of Galati. We analysed 151 questionnaires sent to a sample of students listed in various first-year university courses. The results of this survey ultimately allow us to better identify the time-related, financial, and social factors of stress and the resulting symptoms. It is very clear that the COVID-19 pandemic has had a detrimental effect on this already fragile young population. Our study is also an opportunity to discuss ways to better manage student stress.

ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection.

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding receptor ACE2 and the spike protein priming protease TMPRSS2 are coexpressed in human placentae. It is unknown whether their expression is altered in the context of HIV infection and antiretroviral therapy (ART). METHODS: We compared mRNA levels of SARS-CoV-2 cell-entry mediators ACE2, TMPRSS2, and L-SIGN by quantitative polymerase chain reaction in 105 placentae: 45 from pregnant women with HIV (WHIV) on protease inhibitor (PI)-based ART, 17 from WHIV on non-PI-based ART, and 43 from HIV-uninfected women. RESULTS: ACE2 levels were lower, while L-SIGN levels were higher, in placentae from WHIV on PI-based ART compared to those on non-PI-based ART and to HIV-uninfected women. TMPRSS2 levels were similar between groups. Black race was significantly associated with lower expression of ACE2 and higher expression of L-SIGN. ACE2 levels were significantly higher in placentae of female fetuses. CONCLUSIONS: We identified pregnant women of black race and WHIV on PI-based ART to have relatively lower expression of placental ACE2 than those of white race and HIV-uninfected women. This may potentially contribute to altered susceptibility to COVID-19 in these women, favorably by reduced viral entry or detrimentally by loss of ACE2 protection against hyperinflammation.

A child's right to protection during the COVID-19 crisis: An exploratory study of the child protective services of Estonia.

In 2019 the novel Coronavirus COVID-19 was discovered, and the following year the World Health Organization declared a pandemic. This pandemic is unprecedented in human history and affects all aspects of life. In this article, we explore the pandemic's impact on child protective services in Estonia and survey a representative sample of child protection workers (n = 81), asking three open-ended questions designed to explore child protection practice. These questions concern the impact on organisational design, the workers' ability to conduct a diagnosis of a child's care context, and what knowledge they could draw upon, as well as the decision itself. The overall findings indicate that the organisational design left practice unprepared; there was a general lack of ability to act upon referrals and also to conduct investigations to evaluate care contexts. Furthermore, there is a general lack of knowledge of how to deal with protective practices and conduct decision-making during crisis situations.